The patient states “it is maybe a mild shingles; an acne like break out; they popped when I showered; is creeping to the upper part of the back; bumpy blistery rash; This non-serious case was reported by a consumer via call center representative and described the occurrence of shingles in a 52-year-old female patient who received Herpes zoster (Shingrix) for prophylaxis. Additional patient notes included The patient was red haired person. On 08-DEC-2024, the patient received the 1st dose of Shingrix (intramuscular, right arm). On 13-DEC-2024, 5 days after receiving Shingrix, the patient experienced rash (Verbatim: is creeping to the upper part of the back) and blistery rash (Verbatim: bumpy blistery rash). On an unknown date, the patient experienced shingles (Verbatim: The patient states “it is maybe a mild shingles), acne (Verbatim: an acne like break out) and blister (Verbatim: they popped when I showered). The patient was treated with hydrocortisone (Cortaid). The outcome of the shingles was unknown and the outcome of the rash was not resolved and the outcome of the blistery rash and blister were resolved and the outcome of the acne was not reported. It was unknown if the reporter considered the shingles, rash, blistery rash, acne and blister to be related to Shingrix. It was unknown if the company considered the shingles, rash, blistery rash, acne and blister to be related to Shingrix. Additional Information: GSK Receipt Date: 03-JAN-2025 The reporter reported that the patient received Shingrix and had a rash as a bumpy blistery rash on patient back, with very small blisters. The reporter describes it as an acne like break out. The reporter reported about the blisters as they popped when patient showered. The blisters went away but not the rash. The reporter states the rash was creeping to the upper part of the back. It was maybe a mild shingles. The rash first appeared on the right section of the back, and it has moved to the upper left part of the back, near the neck and the shoulder. It has moved from right to left. The patient will see a dermatologist next week but states that the nurse recommended to take an oral antihistamine and to apply Cortaid topical cream. The patient has used this for a week and states it has helped. The reporter wanted to share the fact that she was a red-haired person. The reporter states red-haired people react differently to medications, and it was a real thing, it was crazy. The reporter stated we can overreact to medications, and with anesthesia they give less or more depending on the patient, and the patient always overreact to medications.