Pt was given the TdaP vaccine in her left deltoid by MA in usual protocol. Approx 30 seconds after vaccine was administered she developed pain at the injection site that progressed to the left breast. Dr came back to the exam room to evaluate patient. She was rocking back and forth holding her left arm with ice pack in place. Dr laid patient back on the exam table with the HOB elevated and asked for EpiPen to be available in the exam room. Patient reported pain progressed up the left side of her chest, neck and head. She then developed HA with pain behind the left eye and jaw tightness. Dr asked for EMS to be called, patient aware. Dr noticed a darkening of the skin of both eyelids and under the eyes. Discoloration then started in the perioral area. Patient then developed some throat tightness. A single dose of EpiPen was administered into the lateral R thigh at 11:51a. Patient reported breathing better approx 2-3 min after Epi was delivered. She denied abdominal pain, nausea, vomiting. Patient was taken to hospital by ambulance. TdaP added to allergy list.