On January 16, 2025, donor received first Anti-HBS immunization. Within 15 minutes of the immunization, the donor started to experience itchy and swelling on the left hand. A rash developed on the donor’s hand and finger. Donor was monitored and ice pack placed on hand. Donors breathing and heart rate remained normal and denied any other symptoms. Donor’s vital signs remained within normal limits. Donor was monitored for approximately 20 minutes in which the hand color returned to normal. The itching and swelling subsided almost immediately after ice pack was placed.