Pt has occupational risk of exposure to orthopoxviruses as individual who directly handle cultures or animals contaminated or infected with monkeypox virus. Jynneos booster given on 1/22/25 to left arm is noted to be red, indurated and slight warmness to area where vaccine was given. Redness measures 20 x 10 cm. Induration is 14cm long. Pt notes that he experienced joint pain, myalgia, and fatigue following Jynneos injection that improved on 1/23/25 evening. Pt notes injection site was itchy. Pt notes injection site caused a dull ache pain in the center of the induration. Discomfort was up to 6/10 on pain scale. Pt notes pain on 1/24/25 is much better at a 1-2/10.